Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as additive to the UV filter avobenzone in cosmetic sunscreen formulations – Evaluation. DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE. Health Concerns of the Ingredient: Overall Hazard. Cancer. Developmental & reproductive toxicity. Opinion on diethylamino hydroxybenzoyl hexyl benzoate. 2. About the Scientific Committees. Three independent non-food Scientific.
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Diethylamino hydroxybenzoyl hexyl benzoate 0. Reducing the amount of harmful sunscreen components that reach the reef environment is a high priority and will require the involvement of governments, reef managers, divers, snorkelers and swimmers, and the tourism and pharmaceutical industries. Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at nm [ 1 ].
Diethylamino hydroxybenzoyl hexyl benzoate
Damage to coral DNA and to their reproductive success. They also contain inactive ingredients such as anti-microbial preservatives, moisturisers and anti-oxidants. On the reef, while UV filters may be at lower concentrations, they can accumulate in organisms and sediment and thus become persistent, with largely unknown consequences.
Researching the extent and significance of bio-concentration and bio-accumulation hydroxybenzkyl organic UV filters as well as the consequences diethhlamino long-term, chronic exposure to sunscreen pollutants. The chemical UV filter oxybenzone has been studied most intensively and the following effects have been described: Bleaching of coral fragments and coral cells from various species of hard coral. In general, concentrations of UV filters used in experimental work have been higher than likely to be encountered in the reef environment.
Further research is needed to better understand which ingredients are safe and which pose a realistic threat to marine ecosystems, in particular: Investigating the effects of sunscreen pollutants at reef community and ecosystem level. Impacts of sunscreens on coral reefs. Diethylamino hydroxybenzoyl hexyl benzoate was not shown to be mutagenic, clastogenic, or phototoxic in vitro [ 4 ].
In vitrotopical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by diethylamono oedema formation [ 3 ]. Damage and deformation of coral larvae planulae.
Encouraging the manufacture of reef-friendly sunscreens.
Diethylamino Hydroxybenzoyl Hexyl Benzoate
Drug created on December 03, Research to date has also concentrated mainly on the effects of sunscreens and individual chemicals at subcellular, cellular and individual organism level, with very few studies of wider impacts. Like other UV filters, diethylamino hydroxybenzoyl hexyl benzoate may be subject to photodegradation upon absorption of UV radiation, which results in the compound passing from a ground state to either a singlet or triplet excited state [ 1 ].
Further research is needed to better understand which ingredients are safe and which pose a realistic threat to marine ecosystems, in particular:. Based on the findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum [ 4 ].
The following measures are recommended: It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability [ 1 ].
The following measures are recommended:. Studying the effects of pharmaceutical and personal care products PPCP mixtures to provide a more realistic picture of ecological risks posed by the use of these products.
Many of hydroxybnzoyl components have also been found in marine biota including fish, molluscs and corals as well as in sediments.
This effect is more pronounced at higher water temperatures. A small number of studies have shown that sunscreen and certain individual components of sunscreen can have negative effects on corals and other marine organisms under certain circumstances. Induction of the lytic viral cycle in symbiotic zooxanthellae with latent infections.
Identifying those ingredients that are safe and those that pose a realistic threat to marine ecosystems. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions [ 4 ].
Most experiments have also been of relatively short duration 12 or 24 hours. To date, experiments have largely been undertaken ex-situ and there are diethylamimo that they may not properly reflect conditions on the reef, where pollutants could be rapidly dispersed and diluted.
In rat and porcine skin, the percutaneous absorption was 0. Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe inand is also marketed in the U.
Diethylamino hydroxybenzoyl hexyl benzoate – Wikiwand
Where sunscreen components have been detected, concentrations are very variable. Considering the many stresses already faced by reefs and current concerns about the toxicity of certain components of sunscreens to corals, a proactive and precautionary approach to dealing with this issue may be required.
Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin [ 2 ]. The chemical UV filter oxybenzone has been studied most intensively and the following effects have been described:. They are generally found at barely detectable levels of a few parts per trillion but much higher concentrations of over 1 part per million ppm have been reported in a few locations e.
No case of overdose has been reported. Investigating UV filter toxicity in relation to predicted warming and ocean acidification conditions. Diethylamino hydroxybenzoyl hexyl benzoate.