BRITISH ANTI LEWISITE PDF

British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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Its original name reflects its origins as a compound secretly developed by British biochemists at Oxford University during World War II [13] [14] as an antidote for lewisitea now-obsolete arsenic -based chemical llewisite agent.

Although treatment with dimercaprol will increase the excretion of cadmium, there is a concomitant increase in renal cadmium concentration, so that its use in case of cadmium toxicity is to be avoided.

Dimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs.

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Goals and duration of treatment. Dimercaprol Edetates Prussian blue. Skeletal formula and ball and stick model of dimercaprol. Views Read Edit View history. Site license users, click the Site License Acces link on the Homepage at an authorized lfwisite.

Dimercaprolalso called British anti-Lewisite BALis a medication used to treat acute poisoning by arsenicmercurygoldand lead. In other projects Wikimedia Commons. We welcome suggested improvements to any of our articles. By32 articles had been published or were in press on the therapeutic value of BAL Ord Experimental observations revealed that dimercaprol may be an effective neuroprotective agent.

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This page was last edited on 13 Novemberat Parenteral British anti-Lewisite can be successfully used in brifish poisoning if oral therapy fails. It was believed to have much greater toxicity than mustard gas, with some animal data suggesting that as little as one-third teaspoon on the skin would result in human death Vilensky By using this site, you agree to the Terms lewisit Use and Privacy Policy. During and after the war, nonmilitary uses for the heavy metal chelating action of BAL became apparent.

The effects were definitive and dramatic; the patients exhibited great improvement in accordance with marked increases in urinary copper excretion Cummings ; Denny-Brown and Porter By the end of World War IIdimercaprol had also been found useful as an antidote against poisoning by several metals and semimetals—including arsenicgoldleadand mercury—that act by combining with cellular sulfhydryl groups.

If you are a subscriber, please log in. Retrieved 8 December Dimercaprol is more effective if its use is begun within two hours after ingestion of the toxic metal.

Because of its instability in water, it is administered by intramuscular injection of a solution of it in peanut oil. More About Dimercaprol 1 reference found in Britannica articles Assorted References arsenic poisoning In arsenic poisoning. Common side effects include high blood pressurepain at the site of the injection, vomiting, and fever. At the bottom of the article, feel free to list any sources that support your changes, so that we can fully understand their context.

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Retrieved from ” https: However, it is not necessarily the treatment of choice for toxicity to these metals. BAL s use as lewisitf primary treatment for Wilson disease was short-lived because Walshe, inshowed the value of the less toxic chelating agent, penicillamine Walshe There was a problem with your submission.

Human and Experimental Toxicology Archived from the original on Learn More in these related Britannica articles: Dimercaprol also enhances the leaisite of selenium and telluriumso it is not to be used to remove these elements from the body.

British anti-Lewisite is used in arsenic, gold, and mercury soluble inorganic compounds poisoning. Our editors will review what you’ve submitted, and if it meets our criteria, we’ll add it to the article. Copper sulfate Ipecacuanha Syrup of ipecac. Retrieved 22 April International journal of immunopathology antl pharmacology.

British anti-Lewisite :: Development

Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, [8] and it remains an essential drug. Nevertheless, BAL may still have some therapeutic value in patients who do not respond well to more modern agents Scheinberg and Sternlieb Internet URLs are the best.

This drug is not indicated in patients with iron, cadmium, selenium, silver, or uranium poisoning.